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عدد المساهمات : 240
تاريخ التسجيل : 31/08/2008
 |  موضوع: المكتبة الشاملة لكتب الصيدلة  27.11.08 9:56 | |
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The Goodman and Gilman Manual of Pharmacology and Therapeutics
Publisher: McGraw-Hill Professional Number Of Pages: 1984 Publication Date: 2005-10-28 ISBN-10 / ASIN: 0071422803 ISBN-13 / EAN: 9780071422802 Book Description: The undisputed leader in medical pharmacology, without equal. Updated to reflect all critical new developments in drug action and drug-disease interaction. This is the “desert island” book of all medical pharmacology—if you can own just one pharmacology book, this is it.Summary: Essential Pharmacology TextRating: 5Every pharmaceutcial chemist and pharmacologist needs a copy of this book. No other textbook comes close.Summary: A complete Pharmacological EncyclopediaRating: 5This book is a complete pharmacological encyclopedia from its days of inception.It is useful to any physician as a desk reference. Professor K.Neelakantan Viswanathan, AVMC, Pondicherry, India Bernard Testa, Han van de Waterbeemd, Gerd Folkers, Richard Guy
“Pharmacokinetic Optimization in Drug Research"
Wiley-VCH 2002-09 ISBN: 3906390225 668 pages PDF 4,8 Mb
In this age of combinatorial chemistry and high-throughput technologies, bioactive compounds called hits are discovered by the thousands. However, the road that leads from hits to lead compounds and then to pharmacokinetically optimized clinical and drug candidates is very long indeed. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming develop-ment and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, drug researchers are coming to incorporate structure-permeation, structure-distribution, structure-metabolism, and structure-toxicity relations into drug-design strategies. To this end, powerful biological, physicochemical, and computational approaches are being developed whose objectives are to increase the clinical relevance of drug design, and to eliminate as soon as possible compounds with unfavorable physicochemical properties and pharmacokinetic profiles. Toxicological issues are also of utmost importance in this paradigm.
There was, hence, an urgent need for a book covering this field in an authoritative, didactic, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international authorities and practicing experts from academia and industry present the most modern biological, physicochemical, and computational strategies to optimize gastrointestinal absorption, protein binding and distribution, brain permeation, and metabolic profile. The biological strategies emphasized in the book include cell cultures and high-throughput screens. The physicochemical strategies focus on the determination and interpretation of solubility, lipophilicity, and related molecular properties as factors and predictors of pharmacokinetic bahavior. Particular attention is paid to the lipophilicity profiles of ionized compounds, to lipophilicity measurements in anisotropic media (liposomes/water, IAM columns), and to permeability across artificial membranes. Computational strategies comprise virtual screening, molecular modelling, lipophilicity, and H-bonding fields and their importance for structure-disposition relations.
This book is both about theoretical and technological breakthroughs. Thus, molecular properties are contemplated from a dual perspective, namely a) their interpretation in biological and/or physicochemical terms, and b) their value in screening, lead optimization, and drug-candidate selection.depositfiles.com  b]James A. Duke, Mary Jo Bogenschutz-Godwin "CRC Handbook of Medicinal Spices"[/b]
CRC ISBN 0849312795 2002-09-27 360 Pages PDF 3.6 Mb
"Let food be your medicine, medicine your food." -Hippocrates, 2400 B.C. When the "Father of Medicine" uttered those famous words, spices were as important for medicine, embalming, preserving food, and masking bad odors as they were for more mundane culinary matters. Author James A. Duke predicts that spices such as capsicum, cinnamon, garlic, ginger, onion, and turmeric will assume relatively more medicinal importance again, as the economic costs and knowledge of the side-effects of prescription pharmaceuticals increase. After all, each spice contains thousands of useful phytochemicals. Pharmaceuticals usually contain only one or two. Discover the Science behind the Folklore Spices are important medicines that have withstood the empirical tests of millennia. Nearly 5,000 years ago Charak, the father of Ayurvedic medicine, claimed that garlic lightens the blood, reduces tumors, and is an aphrodisiac tonic. Today scientists say it thins the blood, prevents cancer, and increases libido. For centuries people worldwide have used spices to cure a myriad of ailments and to preserve foods. Now science is proving that these spices may preserve us with their antioxidant and antiseptic activities. Organized by scientific name, the CRC Handbook of Medicinal Spices provides the science behind the folklore of over 60 popular spices. For each spice, it lists: Scientific name Common name Medicinal activities and indications Multiple activities Other uses, especially culinary Cultivation Chemistry Important phytochemical constituents and their activities The handbook also includes market and import data, culinary uses, ecology and cultural information, and discusses at length the use of spices as antiseptics and antioxidants.Rapidshare FileFactory Easy-Share Megaupload
Sidney H. Willig, James R. Stoker "Good Manufacturing Practices for Pharmaceuticals: A Plan for Total Quality Control"
Marcel Dekker Number Of Pages: 496 1996-09-12 ISBN: 0824797701 PDF 8 Mb
2 Editions OF ItGoodman & Gilman's The Pharmacological Basis of Therapeutics | |
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